Not genetics, lifestyle leads to most premature heart diseases

Washington: Physical inactivity, smoking, high blood pressure, diabetes, and high cholesterol play a greater role than genetics in many young patients with heart diseases, suggests a new study.
The research presented today at ‘ESC Congress 2019’ showed that healthy behaviours should be a top priority for reducing heart disease even in those with a family history of early-onset.
“Genetics is an important contributor to premature heart disease but should not be used as an excuse to say it is inevitable,” said study author, Dr Joao A. Sousa of Funchal Hospital.
“In our clinical practice, we often hear young patients with premature heart disease ‘seek shelter’ and explanations in their genetics/family history,” he said.
“However, when we look at the data in our study, these young patients were frequent smokers, physically inactive, with high cholesterol levels and high blood pressure – all of which can be changed,” he added. The study enrolled 1,075 patients under 50, of whom 555 had coronary artery disease (known as premature CAD). Specific conditions included stable angina, heart attack, and unstable angina.
The average age was 45 and 87 per cent were men. Risk factor levels and genetics in patients were compared to a control group of 520 healthy volunteers (average age 44, and 86 per cent men). Patients and controls were recruited from the Genes in Madeira and Coronary Disease (GENEMACOR) database.