Exercising muscle may ward off chronic inflammation on its own

New York, Jan 24 : Human muscle has an innate ability to ward off the damaging effects of chronic inflammation when exercised, a new study suggests.
The study, published in the journal Science Advances, indicates that inflammation is not inherently good or bad. When the body is injured, an initial low-level inflammation response clears away debris and helps tissue rebuild.
“Our engineered muscle platform is modular, meaning we can mix and match various types of cells and tissue components if we want to. But in this case, we discovered that the muscle cells were capable of taking anti-inflammatory actions all on their own,” said researcher Nenad Bursac, Professor at Duke University.
Among many molecules that can cause inflammation, one pro-inflammatory molecule in particular, interferon gamma, has been associated with various types of muscle wasting and dysfunction.
While previous research in humans and animals has shown that exercise can help mitigate the effects of inflammation in general, it has been difficult to distinguish what role the muscle cells themselves might play, let alone how they interact with specific offending molecules, such as interferon gamma.
To prove that muscle alone is capable of blocking interferon gamma’s destructive powers, the team turned to an engineered muscle platform that the laboratory has been developing for nearly a decade.